Molecularly imprinted polymers for solid-phase extraction

The features of molecular imprinted polymers (MIP) were investigated for their use in solid-phase extraction. A conventional suspension polymerization method, which uses an organic solvent mixture containing functional monomer, cross-linker and initiator, and water containing a suspension stabilizer, was combined with a molecular imprinting technique to prepare beaded polymers. The MIP for a target compound was prepared by using a functional monomer and crosslinker by a multi-step swelling and thermal polymerization method. The results show that added of GMMA and GDMA could be adsorbed on the surface of the base particles, and that the molecularly imprinted sites remained unchanged after hydrophilic surface modification.