Collapsing glomerulopathy

被引：115

作者：

Albaqumi, Mamdouh

Soos, Timothy J.

Barisoni, Laura

Nelson, Peter J.

机构：

[1] NYU, Sch Med, Smilow Res Ctr, Div Nephrol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2006年 / 17卷 / 10期

关键词：

D O I：

10.1681/ASN.2006030225

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Collapsing glomerulopathy (CG) has become an important cause of ESRD. First delineated from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common, distinct pattern of proliferative parenchymal injury that portends a rapid loss of renal function and poor responses to empiric therapy. Notwithstanding, the rise in disorders that are associated with CG, the identification of the first susceptibility genes for CG, the remarkable increase in murine modeling of CG, and promising preclinical testing of new therapeutic strategies suggest that the outlook for CG as a poorly understood and therapeutically resistant renal disease is set to change in the future. This focused review highlights recent advances in research into the pathogenesis and treatment of CG.

引用

收藏

页码：2854 / 2863

页数：10

相关论文

共 132 条

[51] Fulminant acute nephrotic syndrome in a patient with idiopathic collapsing focal segmental glomerulosclerosis after a febrile illness [J].

Hamad, A ;

Balsam, L .

AMERICAN JOURNAL OF NEPHROLOGY, 2001, 21 (01) :84-85

[52] Cutting edge:: Multiple autoimmune pathways in kd/kd mice [J].

Hancock, WW ;

Tsai, TL ;

Madaio, MP ;

Gasser, DL .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :2778-2781

[53] Transgenic mice expressing human immunodeficiency virus type 1 in immune cells develop a severe AIDS-like disease [J].

Hanna, Z ;

Kay, DG ;

Cool, M ;

Jothy, S ;

Rebai, N ;

Jolicoeur, P .

JOURNAL OF VIROLOGY, 1998, 72 (01) :121-132

[54] In vivo mutational analysis of the N-terminal region of HIV-1 Nef reveals critical motifs for the development of an AIDS-like disease in CD4C/HIV transgenic mice [J].

Hanna, Z ;

Priceputu, E ;

Kay, DG ;

Poudrier, J ;

Chrobak, P ;

Jolicoeur, P .

VIROLOGY, 2004, 327 (02) :273-286

[55] The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck [J].

Hanna, Z ;

Weng, XD ;

Kay, DG ;

Poudrier, J ;

Lowell, C ;

Jolicoeur, P .

JOURNAL OF VIROLOGY, 2001, 75 (19) :9378-9392

[56] Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice [J].

Hanna, Z ;

Kay, DG ;

Rebai, N ;

Guimond, A ;

Jothy, S ;

Jolicoeur, P .

CELL, 1998, 95 (02) :163-175

[57] IKK2 inhibitor alleviates kidney and wasting diseases in a murine model of human AIDS [J].

Heckmann, A ;

Waltzinger, C ;

Jolicoeur, P ;

Dreano, M ;

Kosco-Vilbois, MH ;

Sagot, Y .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (04) :1253-1262

[58] Selective COX-2 inhibitors and renal injury in salt-sensitive hypertension [J].

Hermann, M ;

Shaw, S ;

Kiss, E ;

Camici, G ;

Bühler, N ;

Chenevard, R ;

Lüscher, TF ;

Gröne, HJ ;

Ruschitzka, F .

HYPERTENSION, 2005, 45 (02) :193-197

[59]

HU C, 2005, J AM SOC NEPHOROL A, V16, pA652

[60] HIV-1 Nef induces dedifferentiation of podocytes in vivo:: a characteristic feature of HIVAN [J].

Husain, M ;

D'Agati, VD ;

He, JCJ ;

Klotman, ME ;

Klotman, PE .

AIDS, 2005, 19 (17) :1975-1980

← 1 2 3 4 5 6 7 8 9 10 →