AAV: An Overview of Unanswered Questions

被引：97

作者：

Berns, Kenneth I. ^{[1
]}

Muzyczka, Nicholas ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, 2033 Mowry Rd,Rm CG208, Gainesville, FL 32610 USA

来源：

HUMAN GENE THERAPY | 2017年 / 28卷 / 04期

关键词：

AAV toxicity; AAV persistence; AAV immunity; AAV cell interactions; ADENO-ASSOCIATED VIRUS; HUMAN-PAPILLOMAVIRUS TYPE-16; ADENOASSOCIATED VIRUS; TERMINAL REPETITION; NUCLEOTIDE-SEQUENCE; CAPSID PROTEIN; GENE-TRANSFER; DNA; VECTORS; TRANSDUCTION;

D O I：

10.1089/hum.2017.048

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

AAV has been studied for 55 years and has been developed as a vector for about 35 years. By now, there is a fairly good idea of the dimensions of what would be useful to know to employ AAV optimally as a vector, but there are still many unanswered questions within the system. As with all biological systems, each good experiment raises further questions to answer. This article provides an overview of those areas in which unknown information can be identified and of those questions that have not yet been recognized. Some of these are touched on in the six review articles in this issue of Human Gene Therapy.

引用

收藏

页码：308 / 313

页数：6

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