Two-level antibacterial coating with both release-killing and contact-killing capabilities

被引:340
作者
Li, Zhi
Lee, Daeyeon
Sheng, Xiaoxia
Cohen, Robert E.
Rubner, Michael F.
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
关键词
D O I
10.1021/la0622166
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Using a combination of an aqueous layer-by-layer deposition technique, nanoparticle surface modification chemistry, and nanoreactor chemistry, we constructed thin film coatings with two distinct layered functional regions: a reservoir for the loading and release of bactericidal chemicals and a nanoparticle surface cap with immobilized bactericides. This results in dual-functional bactericidal coatings bearing both chemical-releasing bacteria-killing capacity and contact bacteria-killing capacity. These dual-functional coatings showed very high initial bacteria-killing efficiency due to the release of Ag ions and retained significant antibacterial activity after the depletion of embedded Ag because of the immobilized quaternary ammonium salts.
引用
收藏
页码:9820 / 9823
页数:4
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