Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case-Control Study with Follow-up

被引：11

作者：

Borras-Santos, Alicia ^{[1
,2
]}

Garcia-Aymerich, Judith ^{[1
,3
,4
]}

Jose Soler-Cataluna, Juan ^{[2
,5
,32
]}

Vigil Gimenez, Laura ^{[2
,6
,29
]}

Gea Guiral, Joaquim ^{[2
,7
,8
,26
]}

Rodriguez Chiaradia, Diego ^{[2
,7
]}

Pascual Guardia, Sergi ^{[2
,3
,7
,26
]}

Marcos Rodriguez, Pedro J. ^{[9
,35
]}

Alvarez Martinez, Carlos J. ^{[2
,10
,11
,28
]}

Casanova Macario, Ciro ^{[12
,34
]}

Luis Lopez-Campos, Jose ^{[2
,13
,30
]}

Carrasco Hernandez, Laura ^{[2
,13
,15
,30
]}

Martinez-Gonzalez, Cristina ^{[14
,15
]}

Santos-Perez, Salud ^{[2
,14
,16
]}

Peces-Barba, German ^{[2
,17
]}

Molina Paris, Jesus ^{[18
,28
]}

Roman Rodriguez, Miguel ^{[19
,24
]}

Albert Barbera, Joan ^{[2
,20
,21
,22
,25
]}

Faner, Rosa ^{[2
,22
]}

Agusti, Alvar ^{[2
,20
,21
,22
,25
]}

Cosio, Borja G. ^{[2
,23
]}

Garcia-Cosio Piqueras, Borja ^{[24
]}

Cordova Diaz, Rocio ^{[24
]}

Pan Naranjo, Maria Magdalena ^{[24
]}

Palmer Sancho, Joan ^{[24
]}

Faner Canet, Rosa ^{[25
]}

Roca Torrent, Josep ^{[25
]}

Torralba Garcia, Yolanda ^{[25
]}

Moises Lafuente, Jorge ^{[25
]}

Pedro Pijoan, Anna Maria ^{[25
]}

Hervas Docon, Amparo ^{[25
]}

Herranz, Carmen ^{[25
]}

Sanchez Ruano, Nuria ^{[25
]}

Gea Guiral, Joaquim ^{[2
,7
,8
,26
]}

Rodrigez Chiaradia, Diego A. ^{[26
]}

Rodo-Pin, Anna ^{[26
]}

Martin-Ontiyuelo, Clara ^{[26
]}

Admetllo, Mireia ^{[26
]}

Ballano Castro, Concepcion ^{[26
]}

Gutierrez Martin, Laura ^{[26
]}

Aoiz Linares, Jose Ignacio ^{[26
]}

Mourelo Cereijo, Marta ^{[26
]}

Peces-Barba Romero, German ^{[27
]}

Fernandez Arias, Jose ^{[27
]}

Gotera Rivera, Carolina ^{[27
]}

Martin Bernal, Manuel ^{[27
]}

Gallardo Madueno, Guillermo ^{[27
]}

Alcazar Peral, Andres ^{[27
]}

Palacios Miras, Carmelo ^{[27
]}

Pinedo Moraleda, Maria Teresa ^{[27
]}

机构：

[1] ISGlobal, Barcelona, Spain

[2] CIBER Enfermedades Resp CIBERES, Barcelona, Spain

[3] UPF, Barcelona, Spain

[4] CIBERESP, Barcelona, Spain

[5] Hosp Arnau Vilanova, Serv Neumol, Valencia, Spain

[6] Hosp Univ Parc Tauli, Serv Pneumol, Sabadell, Spain

[7] Hosp del Mar, IMIM, Serv Pneumol, Barcelona, Spain

[8] Univ Pompeu Fabra, DCEXS, Barcelona, Spain

[9] UDC, CHUAC, Direct Proc Asistenciales,SERGAS, Serv Neumol,Inst Invest Biomed A Coruna INIBIC,Ar, La Coruna, Spain

[10] Hosp Univ 12 Octubre, Serv Neumol, Madrid, Spain

[11] Univ Complutense Madrid, Fac Med, Dept Med, Madrid, Spain

[12] Univ La Laguna, Serv Neumol, Unidad Invest, Hosp Univ La Candelaria, Tenerife, Spain

[13] Univ Seville, Unidad Med Quirurg Enfermedades Resp, Inst Biomed Sevilla IBiS, Hosp Univ Virgen del Rocio, Seville, Spain

[14] Hosp Univ Cent Asturias, Serv Neumol, Oviedo, Spain

[15] Hosp Univ Bellvitge, Serv Neumol, Barcelona, Spain

[16] Univ Barcelona, IDIBELL, Barcelona, Spain

[17] Fdn Jimenez Diaz, Univ Hosp, Grp Quiron, Madrid, Spain

[18] Ctr Salud Francia DAO Madrid, Grp Resp SemFYC, Madrid, Spain

[19] Inst Investigat Sanitaria Ias Islas Baleares, Unidad Invest Enfermedades Resp Cron Atenc Primar, Inst Invest Sanitaria Islas Baleares, Palma Mallorca Tenerife, Spain

[20] Hosp Clin Barcelona, Inst Resp, Barcelona, Spain

[21] Univ Barcelona, Barcelona, Spain

[22] Inst Invest August Pi i Sunyer IDIBAPS, Barcelona, Spain

[23] Hosp Univ Son Espases IdISBa, Serv Neumol, Palma de Mallorca, Spain

[24] Hosp Son Espases, Mallorca, Spain

[25] Hosp Clin Barcelona, Barcelona, Spain

[26] Hosp del Mar, Barcelona, Spain

[27] Fdn Jimenez Diaz, Madrid, Spain

[28] Hosp 12 Octubre, Madrid, Spain

[29] Hosp Parc Tauli, Sabadell, Spain

[30] Hosp Virgen del Rocio, Seville, Spain

[31] Hosp Univ Bellvitge, Barcelona, Spain

[32] Hosp Arnau Vilanova, Valencia, Spain

[33] Hosp Univ Cent Asturias, Oviedo, Spain

[34] Hosp Candelaria, Canarias, Spain

[35] Hosp Univ A Coruna, La Coruna, Spain

来源：

ARCHIVOS DE BRONCONEUMOLOGIA | 2019年 / 55卷 / 06期

关键词：

Early onset; Natural history; Biomarker; Smoking; FOOD FREQUENCY QUESTIONNAIRE; LUNG-FUNCTION; RISK-FACTORS; COPD; VALIDATION; REPRODUCIBILITY; EXACERBATIONS; GUIDELINES; VALIDITY; DYSPNEA;

D O I：

10.1016/j.arbres.2018.09.007

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Introduction and objectives: Determinants of chronic obstructive pulmonary disease (COPD) in the early stages of its natural history are not well known. Improving our knowledge of these factors will help to design interventions that can modify prognosis. Study objectives are: a) to characterize a COPD population of young adults aged 35-50 years from a multidimensional point of view; b) to compare these patients with smokers with normal lung function: and c) to create a cohort of young adults aged 35-50 years (smokers or former smokers), with and without COPD, who will be followed in the future to improve understanding of the natural history of the disease. Participants and method: This is a case-control multicenter study aimed at establishing a well characterized cohort of young adults, smokers or former-smokers, with and without COPD, for subsequent follow-up. A total of 311 participants (101 cases and 210 controls) were selected from approximately 30 primary care settings and 12 hospitals in 8 Spanish regions. Subjects were smokers or former smokers (> 10 pack-years) aged 35-50 years. Diagnosis of COPD was based on a post-bronchodilator result of FEV1/FVC < 70%. The main study variables were: questionnaires on health, symptoms, exacerbations and daily physical activity, lung function tests, blood and sputum samples, and low-dose computed tomography. In the statistical analysis, COPD patient characteristics will be described and compared with control subjects using a logistic regression analysis. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.

引用

页码：312 / 318

页数：7

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