Topiramate as add-on drug in severe myoclonic epilepsy in infancy:: an Italian multicenter open trial

被引:108
作者
Coppola, G
Capovilla, G
Montagnini, A
Romeo, A
Spanò, M
Tortorella, G
Veggiotti, P
Viri, M
Pascotto, A
机构
[1] Univ Naples 2, Dept Pediat, Clin Child Neuropsychiat, I-80131 Naples, Italy
[2] Child Neuropsychiat C Poma Hosp, Mantua, Italy
[3] Fatehenefratelli Hosp, Milan, Italy
[4] Univ Messina, Clin Child Neuropsychiat, Messina, Italy
[5] Fondaz Neurol C Mondino, IRCCS, Dept Child Neuropsychiat, Pavia, Italy
关键词
refractory seizures; topiramate; severe myoclonic epilepsy infancy;
D O I
10.1016/S0920-1211(02)00010-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: This study was to evaluate the efficacy and safety of topiramate (TPM) in patients with severe myoclonic epilepsy in infancy (SMEI) and refractory seizures. Methods: We performed a prospective multicentric open label add-on studs in IS patients (age 2-21 years. mean 9 years) with SMEI and refractors seizures of different types. TPM was added to one or two other baseline drugs and the efficacy was rated according to seizure type and frequency. Results: TPM was initiated at a daily dose of 0.5-1 mg kg, followed by a 2-week titration at increments of 1-3 mg/kg/24 h up to a maximum daily dose of 12 mg/kg. After a mean period of 11.9 months (range 2-24 months), three patients (16.7%) had 100% fewer seizures and ten patients (55.5%) had a more than 50% seizure decrease. In no patient there was a seizure worsening. Mild to moderate adverse events were present in four patients represented by weight loss, hypermenorrhoea, renal microlithiasis, nervousness and dysarthric speech. Conclusion: TPM may be a useful drug in patients with SMEI, being particularly effective against generalized tonic-clonic seizures. Further studies are needed to evaluate the early use of this drug in such a severe syndrome. (C) 2002 Published by Elsevier Science B.V.
引用
收藏
页码:45 / 48
页数:4
相关论文
共 15 条
[11]   Topiramate in the treatment of severe myoclonic epilepsy in infancy [J].
Nieto-Barrera, M ;
Candau, R ;
Nieto-Jimenez, M ;
Correa, A ;
Del Portal, LR .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2000, 9 (08) :590-594
[12]   A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome [J].
Sachdeo, RC ;
Glauser, TA ;
Ritter, F ;
Reife, R ;
Lim, P ;
Pledger, G .
NEUROLOGY, 1999, 52 (09) :1882-1887
[13]  
Uldall P, 1999, Eur J Paediatr Neurol, V3, P105, DOI 10.1016/S1090-3798(99)90097-1
[14]  
Wheless James W., 2000, Journal of Child Neurology, V15, pS7
[15]  
Yeung S, 2000, Eur J Paediatr Neurol, V4, P31, DOI 10.1053/ejpn.1999.0257