Immunogenicity of rDNA-derived pharmaceuticals

被引：46

作者：

Ryff, JC

Schellekens, H

机构：

[1] BRAIN, Biotech Res & Innovat Network, CH-4052 Basel, Switzerland

[2] Univ Utrecht, Ctr Innovat Studies, Cent Lab Anim Inst, NL-3508 TD Utrecht, Netherlands

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 06期

关键词：

D O I：

10.1016/S0165-6147(02)02024-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Many biopharmaceuticals have been reported to induce the production of antibodies. Several factors influence immunogenicity, including the methods of production, formulation and storage as well as patient characteristics (e.g. type of disease and genetic background). Because immunogenicity is unpredictable, testing for antibodies should always be part of the evaluation of new biopharmaceuticals, although the biological consequences of these antibodies are rarely severe.

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页码：254 / 256

页数：3

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