Marrow stromal cells as steam cells for nonhematopoietic tissues

被引：3454

作者：

Prockop, DJ

机构：

[1] Center for Gene Therapy, Allegheny Univ. of the Hlth. Sci., MCP-Hahnemann School of Medicine, Philadelphia, PA 19102

来源：

SCIENCE | 1997年 / 276卷 / 5309期

关键词：

D O I：

10.1126/science.276.5309.71

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic: The cells have many df the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

引用

页码：71 / 74

页数：4

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