Marrow stromal cells as steam cells for nonhematopoietic tissues

被引：3454

作者：

Prockop, DJ

机构：

[1] Center for Gene Therapy, Allegheny Univ. of the Hlth. Sci., MCP-Hahnemann School of Medicine, Philadelphia, PA 19102

来源：

SCIENCE | 1997年 / 276卷 / 5309期

关键词：

D O I：

10.1126/science.276.5309.71

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic: The cells have many df the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.

引用

页码：71 / 74

页数：4

共 90 条

[61] CULTURED ADHERENT CELLS FROM MARROW CAN SERVE AS LONG-LASTING PRECURSOR CELLS FOR BONE, CARTILAGE, AND LUNG IN IRRADIATED MICE [J].

PEREIRA, RF ;

HALFORD, KW ;

OHARA, MD ;

LEEPER, DB ;

SOKOLOV, BP ;

POLLARD, MD ;

BAGASRA, O ;

PROCKOP, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4857-4861

[62] Use of marrow stromal cells to replace bone cells in a transgenic mouse model for osteogenesis imperfecta. [J].

Pereira, RF ;

Halford, KW ;

OHara, MD ;

Pollard, MD ;

Volpe, P ;

Laptev, A ;

Prockop, DJ .

MATRIX BIOLOGY, 1996, 15 (03) :188-188

[63] IN VIVO DIFFERENTIATION OF HUMAN LEUKOCYTES INTO HISTIOCYTES, FIBROBLASTS AND FAT CELLS IN SUBCUTANEOUS DIFFUSION CHAMBERS [J].

PETRAKIS, NL ;

LUCIA, SP ;

DAVIS, M .

BLOOD, 1961, 17 (01) :109-&

[64] TRANSPLANTATION OF BONE-MARROW FIBROBLASTOID STROMAL CELLS IN MICE VIA THE INTRAVENOUS ROUTE [J].

PIERSMA, AH ;

PLOEMACHER, RE ;

BROCKBANK, KGM .

BRITISH JOURNAL OF HAEMATOLOGY, 1983, 54 (02) :285-290

[65]

PLERSMA AH, 1983, BRIT J HAEMATOL, V54, P285

[66]

PLERSMA AH, 1985, EXP HEMATOL, V13, P237

[67]

QUESENBERRY PJ, 1994, BLOOD CELLS, V20, P348

[68]

QUESENBERRY PJ, 1992, CANCER, V70, P909

[69] ORIGIN OF FIBROBLASTIC GROWTHS IN CHICKEN BUFFY COAT MACROPHAGE CULTURES [J].

RANGAN, SRS .

EXPERIMENTAL CELL RESEARCH, 1967, 46 (03) :477-&

[70] INDUCTION OF RAPID OSTEOBLAST DIFFERENTIATION IN RAT BONE-MARROW STROMAL CELL-CULTURES BY DEXAMETHASONE AND BMP-2 [J].

RICKARD, DJ ;

SULLIVAN, TA ;

SHENKER, BJ ;

LEBOY, PS ;

KAZHDAN, I .

DEVELOPMENTAL BIOLOGY, 1994, 161 (01) :218-228

← 1 2 3 4 5 6 7 8 9 →