A de novo enantioselective total synthesis of (-)-laulimalide

被引：76

作者：

Nelson, SG ^{[1
]}

Cheung, WS ^{[1
]}

Kassick, AJ ^{[1
]}

Hilfiker, MA ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 46期

关键词：

D O I：

10.1021/ja028019k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective total synthesis of the naturally occurring anticancer agent (-)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide-aldehyde cyclocondensation (AAC) reactions and transformations of the derived enantioenriched β-lactones. The synthesis also incorporates a unique allenylstannane glycal acetate alkylation and chemoselective ring-closing metathesis reaction. Copyright © 2002 American Chemical Society.

引用

页码：13654 / 13655

页数：2

共 25 条

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