Synthesis, antitumor activity, molecular modeling, and DNA binding properties of a new series of imidazonaphthalimides

被引：60

作者：

Braña, MF

Cacho, M

García, MA

de Pascual-Teresa, B

Ramos, A

Acero, N

Llinares, F

Muñoz-Mingarro, D

Abradelo, C

Rey-Stolle, MF

Yuste, M

机构：

[1] Univ San Pablo CEU, Fac Ciencias Expt & Salud, Dept Quim Organ, Madrid 28668, Spain

[2] Univ San Pablo CEU, Fac Ciencias Expt & Salud, Dept Biol, Madrid 28668, Spain

[3] Univ San Pablo CEU, Fac Ciencias Expt & Salud, Dept Ciencias Basicas, Madrid 28668, Spain

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2002年 / 45卷 / 26期

关键词：

D O I：

10.1021/jm020950q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of mono and bisintercalators based on the 5,8-dihydrobenz [de]imidazo [4,5-g]isoquinoline-4,6-dione system were synthesized and evaluated for growth inhibitory properties in several human cell lines. All target compounds showed activity in the micromolar range. Representative compounds were evaluated using UV-vis spectroscopy and viscosimetric determinations, showing that they behave as DNA intercalators. Molecular modeling techniques were used in order to rationalize the moderate activity observed for bisnaphthalimides.

引用

页码：5813 / 5816

页数：4

共 23 条

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