Paraneoplastic retinopathies and optic neuropathies

被引:129
作者
Chan, JW [1 ]
机构
[1] Univ Nevada, Sch Med, Dept Internal Med, Div Neurol, Las Vegas, NV 89102 USA
关键词
autoimmune; cancer-associated retinopathy; melanocytic-associated retinopathy; optic neuropathy; paraneoplastic;
D O I
10.1016/S0039-6257(02)00416-2
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Unusual neuro-ophthalmologic symptoms and signs that go unexplained should warrant a thorough investigation for paraneoplastic syndromes. Although these syndromes are rare, these clinical manifestations call herald an unsuspected, underlying malignancy that could be treated early and aggressively. This point underscores the importance of distinguishing and understanding the various, sometimes subtle, presentations of ocular paraneoplastic syndromes. Outlined in this review article are diagnostic features Useful in differentiating cancer-associated retinopathy, melanoma-associated retinopathy, and paraneoplastic optic neuropathy. These must also be distinguished from non-cancer-related eye disorders that may clinically resemble cancer-associated retinopathy. The associated antibodies and histopathology of each syndrome are presented to help in the understanding of these autoimmune phenomena. Treatment outcomes from reported cases are summarized, and some potential novel immunotherapies are also discussed. (C) 2003 by Elsevier Science Inc. All rights reserved.
引用
收藏
页码:12 / 38
页数:27
相关论文
共 150 条
  • [11] ALEXANDER KR, 1992, INVEST OPHTH VIS SCI, V33, P477
  • [12] ALEXIANU ME, 1994, J NEUROCHEM, V63, P2365
  • [13] ANDREASSON S, 1993, ACTA OPHTHALMOL, V71, P487
  • [14] Antoine JC, 2001, ANN NEUROL, V49, P214, DOI 10.1002/1531-8249(20010201)49:2<214::AID-ANA41>3.0.CO
  • [15] 2-W
  • [16] PARA-NEOPLASTIC NIGHT BLINDNESS WITH MALIGNANT-MELANOMA
    BERSON, EL
    LESSELL, S
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1988, 106 (03) : 307 - 311
  • [17] Blumenthal D, 1998, MUSCLE NERVE, V21, P1358, DOI 10.1002/(SICI)1097-4598(199810)21:10<1358::AID-MUS25>3.0.CO
  • [18] 2-X
  • [19] Melanoma-associated paraneoplastic retinopathy: case report and review of the literature
    Boeck, K
    Hofmann, S
    Klopfer, M
    Ian, U
    Schmidt, T
    Engst, R
    Thirkill, CE
    Ring, J
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1997, 137 (03) : 457 - 460
  • [20] PARA-NEOPLASTIC OPTIC NEURITIS AND ENCEPHALOMYELITIS - REPORT OF A CASE
    BOGHEN, D
    SEBAG, M
    MICHAUD, J
    [J]. ARCHIVES OF NEUROLOGY, 1988, 45 (03) : 353 - 356