Palladium-Catalyzed Enantioselective Addition of Two Distinct Nucleophiles across Alkenes Capable of Quinone Methide Formation

被引：144

作者：

Jensen, Katrina H. ^{[1
]}

Pathak, Tejas P. ^{[1
]}

Zhang, Yang ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 47期

基金：

美国国家卫生研究院;

关键词：

INTRAMOLECULAR AMINOOXYGENATION; AEROBIC DIALKOXYLATION; MOLECULAR-OXYGEN; OLEFINS; AMINOHYDROXYLATION; CARBOAMINATION; DIFUNCTIONALIZATION; 2-ALLYLPHENOLS; ACTIVATION; 1,3-DIENES;

D O I：

10.1021/ja909030c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sequential intramolecular-intermolecular enantioselective alkene difunctionalization reaction has been developed which is thought to proceed through Pd-catalyzed quinone methide formation. The synthesis of new chiral heterocyclic compounds with adjacent chiral centers is achieved in enantiomeric ratios up to 99:1 and diastereomeric ratios up to 10:1.

引用

页码：17074 / +

页数：4

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