Evidence for Association Between Polymorphisms in the Cannabinoid Receptor 1 (CNR1) Gene and Cannabis Dependence

被引：58

作者：

Agrawal, Arpana ^{[1
]}

Wetherill, Leah ^{[2
]}

Dick, Danielle M. ^{[3
]}

Xuei, Xiaoling ^{[2
]}

Hinrichs, Anthony ^{[1
]}

Hesselbrock, Victor ^{[4
]}

Kramer, John ^{[5
]}

Nurnberger, John I., Jr. ^{[2
]}

Schuckit, Marc ^{[6
]}

Bierut, Laura J. ^{[1
]}

Edenberg, Howard J. ^{[2
]}

Foroud, Tatiana ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Indiana Univ, Sch Med, Indianapolis, IN USA

[3] VCU, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA

[4] Univ Connecticut, Ctr Hlth, Farmington, CT USA

[5] Univ Iowa, Coll Med, Iowa City, IA USA

[6] Univ Calif San Diego, San Diego, CA 92103 USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2009年 / 150B卷 / 05期

关键词：

CNR1; cannabis dependence; COGA; pedigree disequilibrium test; association; NATIONAL EPIDEMIOLOGIC SURVEY; USE DISORDERS; FAMILIAL TRANSMISSION; SUBSTANCE DEPENDENCE; SMOKING-CESSATION; UNITED-STATES; LINKAGE SCAN; ALCOHOL; DRUG; ABUSE;

D O I：

10.1002/ajmg.b.30881

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Genomic studies of cannabis use disorders have been limited. The cannabinoid receptor 1 gene (CNR1) on chromosome 6q14-15 is an excellent candidate gene for cannabis dependence due to the important role of the G-protein coupled receptor encoded by this gene in the rewarding effects of Delta 9-tetrahydrocannabinol. Previous studies have found equivocal evidence for an association between SNPs in CNR1 and a general vulnerability to substance use disorders. We investigate the association between 9 SNPs spanning CNR1 and cannabis dependence in 1,923 individuals. Two SNPs that were previously associated with cannabis dependence in other studies were also significant with this phenotype in our analyses [rs806368 (P = 0.05) and rs806380 (P = 0.009)]. Haplotype analyses revealed the association to be largely driven by the SNP rs806380. These results suggest a role for the cannabinoid receptor 1 gene in cannabis dependence. (C) 2008 Wiley-Liss, Inc.

引用

页码：736 / 740

页数：5

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