The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing

被引:13
作者
Sackstein, R [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Dept Dermatol, Skin Dis Res Ctr,Med Sch, Cambridge, MA 02138 USA
[2] Harvard Univ, Brigham & Womens Hosp, Dept Med, Skin Dis Res Ctr,Med Sch, Cambridge, MA 02138 USA
[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
关键词
adult stem cell; hematopoietic stem cell; homing; regenerative therapy; selectin;
D O I
10.1016/S0022-202X(15)53011-X
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The recent findings that adult stem cells are capable of generating new blood vessels and parenchymal cells within tissues they have colonized has raised immense optimism that these cells may provide functional recovery of damaged organs. The use of adult stem cells for regenerative therapy poses the challenging task of getting these cells into the requisite sites with minimum morbidity and maximum efficiency. Ideally, tissue-specific colonization could be achieved by introducing the stem cells intravascularly and exploiting the native physiologic processes governing cell trafficking. Critical to the success of this approach is the use of stem cells bearing appropriate membrane molecules that mediate homing from vascular to tissue compartments. Hematopoietic stem cells (HSC) express a novel glycoform of CD44 known as hematopoietic cell E-/L-selectin ligand (HCELL). This molecule is the most potent E-selectin ligand natively expressed on any human cell. This article reviews our current understanding of the molecular basis of HSC homing and will describe the fundamental "roll" of HCELL in opening the avenues for efficient FISC trafficking to the bone marrow, the skin and other extramedullary sites.
引用
收藏
页码:215 / 223
页数:9
相关论文
共 133 条
[61]   Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines [J].
Kulidjian, AA ;
Issekutz, AC ;
Issekutz, TB .
INTERNATIONAL IMMUNOLOGY, 2002, 14 (07) :751-760
[62]   Purified hematopoietic stem cells can differentiate into hepatocytes in vivo [J].
Lagasse, E ;
Connors, H ;
Al-Dhalimy, M ;
Reitsma, M ;
Dohse, M ;
Osborne, L ;
Wang, X ;
Finegold, M ;
Weissman, IL ;
Grompe, M .
NATURE MEDICINE, 2000, 6 (11) :1229-1234
[63]   P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells [J].
Laszik, Z ;
Jansen, PJ ;
Cummings, RD ;
Tedder, TF ;
McEver, RP ;
Moore, KL .
BLOOD, 1996, 88 (08) :3010-3021
[64]   ROLLING OF LYMPHOCYTES AND NEUTROPHILS ON PERIPHERAL NODE ADDRESSIN AND SUBSEQUENT ARREST ON ICAM-1 IN SHEAR-FLOW [J].
LAWRENCE, MB ;
BERG, EL ;
BUTCHER, EC ;
SPRINGER, TA .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (04) :1025-1031
[65]   Threshold levels of fluid shear promote leukocyte adhesion through selectins (CD62L,P,E) [J].
Lawrence, MB ;
Kansas, GS ;
Kunkel, EJ ;
Ley, K .
JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :717-727
[66]   Peripheral lymph node addressins are expressed on skin endothelial cells [J].
Lechleitner, S ;
Kunstfeld, R ;
Messeritsch-Fanta, C ;
Wolff, K ;
Petzelbauer, P .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (03) :410-414
[67]   Coreceptor chemokine receptor expression on human hematopoietic cells: Biological implications for human immunodeficiency virus-type 1 infection [J].
Lee, B ;
Ratajczak, J ;
Doms, RW ;
Gewirtz, AM ;
Ratajczak, MZ .
BLOOD, 1999, 93 (04) :1145-1156
[68]   Importance of E-selectin for firm leukocyte adhesion in vivo [J].
Ley, K ;
Allietta, M ;
Bullard, DC ;
Morgan, S .
CIRCULATION RESEARCH, 1998, 83 (03) :287-294
[69]   Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin [J].
Li, FG ;
Wilkins, PP ;
Crawley, S ;
Weinstein, J ;
Cummings, RD ;
McEver, RP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (06) :3255-3264
[70]  
Lichtman AH, 1997, J IMMUNOL, V158, P3640