Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

被引：1026

作者：

Shackleton, Mark ^{[1
]}

Quintana, Elsa ^{[1
]}

Fearon, Eric R. ^{[2
]}

Morrison, Sean J. ^{[1
,2
]}

机构：

[1] Univ Michigan, Howard Hughes Med Inst, Inst Life Sci, Ctr Stem Cell Biol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

CELL | 2009年 / 138卷 / 05期

关键词：

ACUTE MYELOID-LEUKEMIA; TUMOR-INITIATING CELLS; BREAST-CANCER; MOUSE MODEL; IDENTIFICATION; PROGENITOR; RESISTANCE; MICE; DIFFERENTIATION; TRANSPLANTATION;

D O I：

10.1016/j.cell.2009.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

引用

收藏

页码：822 / 829

页数：8

相关论文

共 39 条

[1]

Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2]

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[3]

Modeling the initiation and progression of human acute leukemia in mice [J].

Barabe, Frederic ;

Kennedy, James A. ;

Hope, Kristin J. ;

Dick, John E. .

SCIENCE, 2007, 316 (5824) :600-604

[4]

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[5]

Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors [J].

Cho, Robert W. ;

Wang, Xinhao ;

Diehn, Maximilian ;

Shedden, Kerby ;

Chen, Grace Y. ;

Sherlock, Gavin ;

Gurney, Austin ;

Lewicki, John ;

Clarke, Michael F. .

STEM CELLS, 2008, 26 (02) :364-371

[6]

Phenotypic characterization of human colorectal cancer stem cells [J].

Dalerba, Piero ;

Dylla, Scott J. ;

Park, In-Kyung ;

Liu, Rui ;

Wang, Xinhao ;

Cho, Robert W. ;

Hoey, Timothy ;

Gurney, Austin ;

Huang, Emina H. ;

Simeone, Diane M. ;

Shelton, Andrew A. ;

Parmiani, Giorgio ;

Castelli, Chiara ;

Clarke, Michael F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) :10158-10163

[7]

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia [J].

Deshpande, Aniruddha J. ;

Cusan, Monica ;

Rawat, Vijay P. S. ;

Reuter, Hendrik ;

Krause, Alexandre ;

Pott, Christiane ;

Quintanilla-Martinez, Leticia ;

Kakadia, Purvi ;

Kuchenbauer, Florian ;

Ahmed, Farid ;

Delabesse, Eric ;

Hahn, Meinhard ;

Lichter, Peter ;

Kneba, Michael ;

Hiddemann, Wolfgang ;

Macintyre, Elizabeth ;

Mecucci, Cristina ;

Ludwig, Wolf-Dieter ;

Humphries, R. Keith ;

Bohlander, Stefan K. ;

Feuring-Buske, Michaela ;

Buske, Christian .

CANCER CELL, 2006, 10 (05) :363-374

[8]

Stem cell concepts renew cancer research [J].

Dick, John E. .

BLOOD, 2008, 112 (13) :4793-4807

[9]

Association of reactive oxygen species levels and radioresistance in cancer stem cells [J].

Diehn, Maximilian ;

Cho, Robert W. ;

Lobo, Neethan A. ;

Kalisky, Tomer ;

Dorie, Mary Jo ;

Kulp, Angela N. ;

Qian, Dalong ;

Lam, Jessica S. ;

Ailles, Laurie E. ;

Wong, Manzhi ;

Joshua, Benzion ;

Kaplan, Michael J. ;

Wapnir, Irene ;

Dirbas, Frederick M. ;

Somlo, George ;

Garberoglio, Carlos ;

Paz, Benjamin ;

Shen, Jeannie ;

Lau, Sean K. ;

Quake, Stephen R. ;

Brown, J. Martin ;

Weissman, Irving L. ;

Clarke, Michael F. .

NATURE, 2009, 458 (7239) :780-U123

[10]

DIFFERENTIATION OF LEUKEMIA-CELLS TO POLYMORPHONUCLEAR LEUKOCYTES IN PATIENTS WITH ACUTE NONLYMPHOCYTIC LEUKEMIA [J].

FEARON, ER ;

BURKE, PJ ;

SCHIFFER, CA ;

ZEHNBAUER, BA ;

VOGELSTEIN, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (01) :15-24

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