A high-resolution comparative radiation hybrid map of equine chromosome 4q12-q22

被引：9

作者：

Dierks, C.

Momke, S.

Drogemuller, C.

Leeb, T.

Chowdhary, B. P.

Distl, O.

机构：

[1] Univ Vet Med Hannover, Inst Anim Breeding & Genet, D-30559 Hannover, Germany

[2] Texas A&M Univ, Coll Vet Med, Dept Vet Anat & Publ Hlth, College Stn, TX 77843 USA

来源：

ANIMAL GENETICS | 2006年 / 37卷 / 05期

关键词：

comparative map; equine chromosome 4; Equus caballus; fluorescent in situ hybridization; radiation hybrid mapping;

D O I：

10.1111/j.1365-2052.2006.01510.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

In this study, we present a comprehensive 5000-rad radiation hybrid map of a 40-cM region on equine chromosome 4 (ECA4) that contains quantitative trait loci for equine osteochondrosis. We mapped 29 gene-associated sequence tagged site markers using primers designed from equine expressed sequence tags or BAC clones in the ECA4q12-q22 region. Three blocks of conserved synteny, showing two chromosomal breakpoints, were identified in the segment of ECA4q12-q22. Markers from other segments of HSA7q mapped to ECA13p and ECA4p, and a region of HSA7p was homologous to ECA13p. Therefore, we have improved the resolution of the human-equine comparative map, which allows the identification of candidate genes underlying traits of interest.

引用

页码：513 / 517

页数：5

共 15 条

[1] COMPARISONS OF RADIATION HYBRID MAPPING AND LINKAGE MAPPING [J].

BISHOP, DT ;

CROCKFORD, GP .

CYTOGENETICS AND CELL GENETICS, 1992, 59 (2-3) :93-95

[2]

BOEHNKE M, 1991, AM J HUM GENET, V49, P1174

[3] Assignment of the COL8A2 gene to equine chromosome 2p15-p16 by FISH and confirmation by RH mapping [J].

Böneker, C ;

Müller, D ;

Kuiper, H ;

Drögemüller, C ;

Chowdhary, BP ;

Distl, O .

ANIMAL GENETICS, 2005, 36 (05) :444-445

[4] The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes [J].

Chowdhary, BP ;

Raudsepp, T ;

Kata, SR ;

Goh, G ;

Millon, LV ;

Allan, V ;

Piumi, F ;

Guérin, G ;

Swinburne, J ;

Binns, M ;

Lear, TL ;

Mickelson, J ;

Murray, J ;

Antczak, DF ;

Womack, JE ;

Skow, LC .

GENOME RESEARCH, 2003, 13 (04) :742-751

[5] STATISTICAL-METHODS FOR POLYPLOID RADIATION HYBRID MAPPING [J].

LANGE, K ;

BOEHNKE, M ;

COX, DR ;

LUNETTA, KL .

GENOME RESEARCH, 1995, 5 (02) :136-150

[6] Cytogenetic localization of 136 genes in the horse:: comparative mapping with the human genome [J].

Milenkovic, D ;

Oustry-Vaiman, A ;

Lear, TL ;

Billault, A ;

Mariat, D ;

Piumi, F ;

Schibler, L ;

Cribiu, E ;

Guérin, G .

MAMMALIAN GENOME, 2002, 13 (09) :524-534

[7] Assignment of BGLAP, BMP2, CHST4, SLC1A3, SLC4A1, SLC9A5 and SLC20A1 to equine chromosomes by FISH and confirmation by RH mapping [J].

Müller, D ;

Kuiper, H ;

Böneker, C ;

Mömke, S ;

Drögemüller, C ;

Chowdhary, BP ;

Distl, O .

ANIMAL GENETICS, 2005, 36 (05) :457-461

[8] International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources [J].

Penedo, MCT ;

Millon, LV ;

Bernoco, D ;

Bailey, E ;

Binns, M ;

Cholewinski, G ;

Ellis, N ;

Flynn, J ;

Gralak, B ;

Guthrie, A ;

Hasegawa, T ;

Lindgren, G ;

Lyons, LA ;

Roed, KH ;

Swinburne, JE ;

Tozaki, T .

CYTOGENETIC AND GENOME RESEARCH, 2005, 111 (01) :5-15

[9] Construction of a medium-density horse gene map [J].

Perrocheau, M ;

Boutreux, V ;

Chadi, S ;

Mata, X ;

Decaunes, P ;

Raudsepp, T ;

Durkin, K ;

Incarnato, D ;

Iannuzzi, L ;

Lear, TL ;

Hirota, K ;

Hasegawa, T ;

Zhu, B ;

de Jong, P ;

Cribiu, EP ;

Chowdhary, BP ;

Guérin, G .

ANIMAL GENETICS, 2006, 37 (02) :145-155

[10]

Philipsson J., 1993, HERITABILITY EQUINE, V25, P38

← 1 2 →