Synthesis of polycyclic heterocycles via a one-pot ortho alkylation/direct heteroarylation sequence

被引：58

作者：

Martins, Andrew ^{[1
]}

Alberico, Dino ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 21期

关键词：

D O I：

10.1021/ol061859+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polycyclic thiophenes and furans were synthesized using a one-pot ortho alkylation/direct heteroarylation reaction sequence. Under the optimized reaction conditions, aryl iodides were coupled with 3-(bromoalkyl) thiophenes or -furans, affording six-and seven-membered annulated ring products via formation of two C-C bonds from two aryl C-H bonds.

引用

页码：4827 / 4829

页数：3

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