Fate of haem iron in the malaria parasite Plasmodium falciparum

被引：215

作者：

Egan, TJ

Combrinck, JM

Egan, J

Hearne, GR

Marques, HM

Ntenteni, S

Sewell, BT

Smith, PJ

Taylor, D

van Schalkwyk, DA

Walden, JC

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Rondebosch, South Africa

[2] Univ Cape Town, Dept Med, Div Pharmacol, ZA-7701 Rondebosch, South Africa

[3] Univ Witwatersrand, Sch Phys, ZA-2050 Johannesburg, South Africa

[4] Univ Witwatersrand, Sch Chem, ZA-2050 Johannesburg, South Africa

[5] Univ Cape Town, Electron Microscope Unit, ZA-7701 Rondebosch, South Africa

来源：

BIOCHEMICAL JOURNAL | 2002年 / 365卷

关键词：

haemozoin; Mossbauer spectroscopy; electron spectroscopic imaging;

D O I：

10.1042/BJ20020793

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61+/-2% of the iron within parasitized erythrocytes, of which 92+/-6% is located within the food vacuole. Of this, 88+/-9% is in the form of haemozoin. Fe-57-Mossbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.

引用

页码：343 / 347

页数：5

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