The chemical mechanism of beta-haematin formation studied by Mossbauer spectroscopy

被引：45

作者：

Adams, PA

Egan, TJ

Ross, DC

Silver, J

Marsh, PJ

机构：

[1] UNIV CAPE TOWN,DEPT CHEM PATHOL,MRC,BIOMEMBRANE RES UNIT,ZA-7925 RONDEBOSCH,SOUTH AFRICA

[2] UNIV ESSEX,DEPT BIOL & CHEM SCI,COLCHESTER CO4 3SQ,ESSEX,ENGLAND

[3] RED CROSS WAR MEM CHILDRENS HOSP,DEPT CHEM PATHOL,INST CHILD HLTH,ZA-7700 RONDEBOSCH,SOUTH AFRICA

来源：

BIOCHEMICAL JOURNAL | 1996年 / 318卷

关键词：

D O I：

10.1042/bj3180025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneous formation of beta-haematin (malaria pigment) from haematin in acetate solution follows pseudo-zero-order and not autocatalytic kinetics. Acetate appears to facilitate the reaction by solubilizing the haematin and acting as a phase-transfer catalyst, a role which, in vivo, could be fulfilled by carboxylic acids or amino acids.

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页码：25 / 27

页数：3

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