S100A8/A9 in Inflammation

被引：1251

作者：

Wang, Siwen ^{[1
,2
]}

Song, Rui ^{[1
,2
]}

Wang, Ziyi ^{[1
,2
]}

Jing, Zhaocheng ^{[1
,2
]}

Wang, Shaoxiong ^{[1
,2
]}

Ma, Jian ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[2] Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[3] Minist Educ, Hunan Key Lab Nonresolving Inflammat & Canc, Key Lab Carcinogenesis & Canc Invas, Key Lab Carcinogenesis,Minist Hlth, Changsha, Hunan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

S100A8; S100A9; inflammation; infection; biomarker; MYELOID-RELATED PROTEINS; CALCIUM-BINDING PROTEINS; PERITONEAL-EXUDATE CELLS; DISTINCT MOLECULAR SIGNATURES; APOPTOSIS-INDUCING ACTIVITY; HUMAN GINGIVAL FIBROBLASTS; ACUTE CORONARY SYNDROMES; INCREASED SERUM-LEVELS; END-PRODUCTS RAGE; ALZHEIMERS-DISEASE;

D O I：

10.3389/fimmu.2018.01298

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.

引用

页数：14

共 166 条

[1]

Abu El-Asrar, Ahmed M. ;

Alam, Kaiser ;

Siddiquei, Mohammad M. ;

Van den Eynde, Kathleen ;

Mohammad, Ghulam ;

De Hertogh, Gert ;

Opdenakker, Ghislain .

OCULAR IMMUNOLOGY AND INFLAMMATION, 2018, 26 (04) :615-624

[2]

Achouiti, Ahmed ;

Vogl, Thomas ;

Van der Meer, Anne J. ;

Stroo, Ingrid ;

Florquin, Sandrine ;

de Boer, Onno J. ;

Roth, Johannes ;

Zeerleder, Sacha ;

van 't Veer, Cornelis ;

de Vos, Alex F. ;

van der Poll, Tom .

EUROPEAN RESPIRATORY JOURNAL, 2015, 46 (02) :464-473

[3]

Achouiti, Ahmed ;

Vogl, Thomas ;

Urban, Constantin F. ;

Rohm, Marc ;

Hommes, Tijmen J. ;

van Zoelen, Marieke A. D. ;

Florquin, Sandrine ;

Roth, Johannes ;

van't Veer, Cornelis ;

de Vos, Alex F. ;

van der Poll, Tom .

PLOS PATHOGENS, 2012, 8 (10)

[4]

FASTTRACK -: Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion:: a novel, early, and sensitive marker of acute coronary syndromes [J].

Altwegg, Lukas A. ;

Neidhart, Michel ;

Hersberger, Martin ;

Mueller, Simone ;

Eberli, Franz R. ;

Corti, Roberto ;

Roffi, Marco ;

Suetsch, Gabor ;

Gay, Steffen ;

von Eckardstein, Arnold ;

Wischnewsky, Manfred B. ;

Luescher, Thomas F. ;

Maier, Willibald .

EUROPEAN HEART JOURNAL, 2007, 28 (08) :941-948

[5]

S100-alarmins: potential therapeutic targets for arthritis [J].

Austermann, Judith ;

Zenker, Stefanie ;

Roth, Johannes .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2017, 21 (07) :739-751

[6]

Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions [J].

Austermann, Judith ;

Friesenhagen, Judith ;

Fassl, Selina Kathleen ;

Ortkras, Theresa ;

Burgmann, Johanna ;

Barczyk-Kahlert, Katarzyna ;

Faist, Eugen ;

Zedler, Siegfried ;

Pirr, Sabine ;

Rohde, Christian ;

Mueller-Tidow, Carsten ;

von Koeckritz-Blickwede, Maren ;

von Kaisenberg, Constantin S. ;

Flohe, Stefanie B. ;

Ulas, Thomas ;

Schultze, Joachim L. ;

Roth, Johannes ;

Vogl, Thomas ;

Viemann, Dorothee .

CELL REPORTS, 2014, 9 (06) :2112-2123

[7]

Bassorgun CI, 2014, GASTROENT RES PRACT, V2014, DOI [10.1155/2014/, DOI 10.1155/2014/]

[8]

HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-κB activities [J].

Benedyk, Malgorzata ;

Sopalla, Claudia ;

Nacken, Wolfgang ;

Bode, Guenther ;

Melkonyan, Harut ;

Banfi, Botond ;

Kerkhoff, Claus .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (08) :2001-2011

[9]

Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: Studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus [J].

Bengtsson, Anders A. ;

Sturfelt, Gunnar ;

Lood, Christian ;

Ronnblom, Lars ;

van Vollenhoven, Ronald F. ;

Axelsson, Bengt ;

Sparre, Birgitta ;

Tuvesson, Helen ;

Ohman, Marie Wallen ;

Leanderson, Tomas .

ARTHRITIS AND RHEUMATISM, 2012, 64 (05) :1579-1588

[10]

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides [J].

Bjork, Per ;

Bjork, Anders ;

Vogl, Thomas ;

Stenstrom, Martin ;

Liberg, David ;

Olsson, Anders ;

Roth, Johannes ;

Ivars, Fredrik ;

Leanderson, Tomas .

PLOS BIOLOGY, 2009, 7 (04) :800-812

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