Methotrexate-induced toxic epidermal necrolysis in a patient with psoriasis

被引：36

作者：

Primka, EJ ^{[1
]}

Camisa, C ^{[1
]}

机构：

[1] CLEVELAND CLIN FDN,DEPT DERMATOL,CLEVELAND,OH 44195

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1997年 / 36卷 / 05期

关键词：

D O I：

10.1016/S0190-9622(97)70029-X

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We describe a fatal case of low-dose methotrexate (MTX) toxicity in a patient with psoriasis, emphasizing the factors that exacerbate MTX toxicity and presenting rescue techniques. The patient had a toxic epidermal necrolysis-like condition. MTX cutaneous reactions ranging from toxic epidermal necrolysis to specific ulcerations have been described. The use of granulocyte colony stimulating factor for leukopenia associated with MTX toxicity is discussed.

引用

页码：815 / 818

页数：4

共 13 条

[1]

CALLEN JP, 1991, SYSTEMIC DRUGS SKIN, P152

[2]

CAMISA C, 1994, PSORIASIS, P285

[3] NECROTIZING VASCULITIS AND EXACERBATION OF PSORIASIS AFTER GRANULOCYTE-COLONY-STIMULATING FACTOR FOR SMALL-CELL LUNG-CARCINOMA [J].