Assembly of kinetochores in vertebrate cells

被引：40

作者：

Fukagawa, T ^{[1
]}

机构：

[1] Natl Inst Genet, Japan Sci & Technol Agcy, JST, PRESTO, Mishima, Shizuoka 4118540, Japan

[2] Grad Univ Adv Studies, Mishima, Shizuoka 4118540, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2004年 / 296卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

centromere; kinetochores; vertebrate cells;

D O I：

10.1016/j.yexcr.2004.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The centromere is a specialized region of each chromosome that is essential for faithful chromosome segregation during mitosis and meiosis in eukaryotic cells. Centromeres are the site at which kinetochores are formed. The kinetochore is responsible for microtubule binding and chromosome movement. In this review, I will focus on recent advances in our understanding of centromere DNAs as sites for kinetochore assembly and the mechanism underlying kinetochore assembly in vertebrate cells. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：21 / 27

页数：7

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