Effects of Sodium Selenite on Aflatoxin B1-Induced Decrease of Ileal IgA+ Cell Numbers and Immunoglobulin Contents in Broilers

被引：38

作者：

He, Yang ^{[1
]}

Fang, Jing ^{[1
]}

Peng, Xi ^{[1
]}

Cui, Hengmin ^{[1
]}

Zuo, Zhicai ^{[1
]}

Deng, Junliang ^{[1
]}

Chen, Zhengli ^{[1
]}

Geng, Yi ^{[1
]}

Lai, Weimin ^{[1
]}

Shu, Gang ^{[1
]}

Tang, Li ^{[1
]}

机构：

[1] Sichuan Agr Univ, Key Lab Anim Dis & Environm Hazards Sichuan Prov, Coll Vet Med, Yaan 625014, Peoples R China

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2014年 / 160卷 / 01期

关键词：

Aflatoxin B-1; Selenium; IgA(+) cell; Immunoglobulins; Ileal mucosal immunity; T-CELL; HUMORAL IMMUNITY; 100; PPB; B-1; SUPPLEMENTATION; SYSTEM; ANTIBODIES; FABRICIUS; APOPTOSIS; TOXICITY;

D O I：

10.1007/s12011-014-0035-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This study was aimed to assess the protective effect of sodium selenite on the ileum mucosal immunologic injury induced by AFB(1). One hundred eighty-one-day-old healthy male Avian broilers were divided into four groups of three replicates and 15 birds per replicate and fed with basal diet (control group), 0.3 mg/kg AFB(1) (AFB(1) group), 0.4 mg/kg Se (+Se group), and 0.3 mg/kg AFB(1) + 0.4 mg/kg Se (AFB(1) + Se group) respectively. The numbers of IgA(+) cells of ileum were determined by immunohistochemistry as well as the contents of sIgA, IgA, IgG, and IgM in the mucosa of ileum by ELISA. Compared with those in the control group, the numbers of IgA(+) cells as well as the sIgA, IgA, IgG, and IgM contents were decreased in the AFB(1) group. However, compared with those in the AFB(1) group, the numbers of IgA(+) cells as well as the sIgA, IgA, IgG, and IgM contents were increased in the AFB(1) + Se group, and these data had no difference between AFB(1) + Se group and control group. It was concluded that 0.3 mg/kg AFB(1) could reduce the humoral immune function of the ileum mucosa, but 0.4 mg/kg supplemented dietary selenium could protect the mucosal humoral immune function from AFB(1)-induced impairment.

引用

页码：49 / 55

页数：7

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