Isolation of 1-methyl-1,2,3,4-tetrahydroisoquinoline-synthesizing enzyme from rat brain: A possible Parkinson's disease-preventing enzyme

被引：51

作者：

Yamakawa, T

Ohta, S

机构：

[1] HIROSHIMA UNIV,SCH MED,INST PHARMACEUT SCI,MINAMI KU,HIROSHIMA 734,JAPAN

[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 236卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.6946

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An endogenous parkinsonism-preventing substance, 1-methyl-1,2,3,4-tetrahydroisoquinoline is enzymatically formed from 2-phenethylamine and pyruvate in rat brain. The enzyme involved was localized in the mitochondrial-synaptosomal fraction of rat brain, solubilized by treatment with sodium deoxycholate, In order to purify the enzyme, gel filtration was carried out. This enzyme may be important in the pathogenesis of Parkinson's disease. (C) 1997 Academic Press.

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页码：676 / 681

页数：6

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