Highly preferential cleavage of unpaired guanines in DNA by a functionalized salen-nickel complex

被引：31

作者：

Routier, S

Bernier, JL

Catteau, JP

Bailly, C

机构：

[1] INSERM,U124,INST RECH CANC,F-59045 LILLE,FRANCE

[2] UNIV SCI & TECH LILLE FLANDRES ARTOIS,URA CNRS 351,CHIM PHYS ORGAN LAB,F-59655 VILLENEUVE DASCQ,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(96)00569-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the presence of oxygen donnor compounds, a functionalized salen-nickel complex poorly cuts double-stranded DNA but induces strong cleavages at guanine residues in the single-stranded region of hairpin oligonucleotides. Copyright (C) 1996 Elsevier Science Ltd

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页码：63 / 66

页数：4

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