Transmissible spongiform encephalopathies: a family of etiologically complex diseases - a review

被引：14

作者：

Bounias, M

Purdey, M

机构：

[1] Univ Avignon, F-807470 Le Lac Dissarles, France

[2] INRA, DSPE, Biomath & Toxicol Unit, F-807470 Le Lac Dissarles, France

[3] High Barn Farm, Taunton T4 3PX, Somerset, England

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2002年 / 297卷 / 1-3期

关键词：

amyloid forms; cupric ion; oxidative shocks; prion structure/pathogenicity;

D O I：

10.1016/S0048-9697(02)00140-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The upsurge of 'mad cow disease' with its human implications has raised the problem of the etiological mechanisms and the similarities or differences underlying the family of transmissible spongiform encephalopathies. Structural properties of prions are reviewed in connection with their natural distribution and functions, factors of transmissibility and mechanisms of pathogenicity. Polymorphism is examined in relation to disease phenotype variants. The role of oxidative factors is emphasized, while raising complexity about the role of copper ions. Further investigation directions are suggested. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：1 / 19

页数：19

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