Adipose-derived mesenchymal stem cell transplantation promotes adult neurogenesis in the brains of Alzheimer's disease mice

被引：132

作者：

Yan, Yufang ^{[1
]}

Ma, Tuo ^{[1
]}

Gong, Kai ^{[1
]}

Ao, Qiang ^{[2
]}

Zhang, Xiufang ^{[1
]}

Gong, Yandao ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Yuquan Hosp, Inst Neurol Disorders, Beijing 100084, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 08期

关键词：

nerve regeneration; stem cells; Alzheimer's disease; adipose-derived mesenchymal stem cells; cell transplantation; cognitive impairment; oxidative stress; neurogenesis; 863; Program; neural regeneration; OXIDATIVE STRESS; MOUSE MODEL; HIPPOCAMPAL NEUROGENESIS; FUNCTIONAL IMPLICATIONS; STEM/PROGENITOR CELLS; DENTATE GYRUS; STROMAL CELLS; PROLIFERATION; ALLOPREGNANOLONE; RECOVERY;

D O I：

10.4103/1673-5374.131596

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In the present study, we transplanted adipose-derived mesenchymal stem cells into the hippocampi of APP/PS1 transgenic Alzheimer's disease model mice. Immunofluorescence staining revealed that the number of newly generated (BrdU) cells in the subgranular zone of the dentate gyrus in the hippocampus was significantly higher in Alzheimer's disease mice after adipose-derived mesenchymal stem cell transplantation, and there was also a significant increase in the number of BrdU(+)/DCX+ neuroblasts in these animals. Adipose-derived mesenchymal stem cell transplantation enhanced neurogenic activity in the subventricular zone as well. Furthermore, adipose-derived mesenchymal stem cell transplantation reduced oxidative stress and alleviated cognitive impairment in the mice. Based on these findings, we propose that adipose-derived mesenchymal stem cell transplantation enhances endogenous neurogenesis in both the subgranular and subventricular zones in APP/PS1 transgenic Alzheimer's disease mice, thereby facilitating functional recovery.

引用

页码：798 / 805

页数：8

共 69 条

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