OXCARBAZEPINE-INDUCED STEVENS-JOHNSON SYNDROME: A CASE REPORT

被引：52

作者：

Lin, Lung-Chang ^{[1
,3
]}

Lai, Ping-Chin ^{[5
]}

Yang, Sheau-Fang ^{[2
]}

Yang, Rei-Cheng ^{[1
,4
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Pathol, Kaohsiung 807, Taiwan

[3] Kaohsiung Med Univ, Grad Inst Med, Div Physiol, Coll Med, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Physiol and Mol Med, Coll Med, Kaohsiung, Taiwan

[5] Chang Gung Mem Hosp, Dept Nephrol, Taipei 10591, Taiwan

来源：

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES | 2009年 / 25卷 / 02期

关键词：

oxcarbazepine; Stevens-Johnson syndrome; TOXIC EPIDERMAL NECROLYSIS; CARBAMAZEPINE;

D O I：

10.1016/S1607-551X(09)70045-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Although carbamazepine (CBZ) is the most common cause of Stevens-Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B*1502 and CBZ-induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA-B*1518/B*4001. HLA-B*1518 is a HLA-B15 variant. The genetic significance of HLA-B*1518 in association with oxcarbazepine-induced SJS needs to be further studied.

引用

页码：82 / 86

页数：5

共 13 条

[1]

Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis - Results of an international prospective study [J].

Auquier-Dunant, A ;

Mockenhaupt, M ;

Naldi, L ;

Correia, O ;

Schroder, W ;

Roujeau, JC .

ARCHIVES OF DERMATOLOGY, 2002, 138 (08) :1019-1024

[2]

Human leukocyte antigens and drug hypersensitivity [J].

Chung, Wen-Hung ;

Hung, Shuen-Lu ;

Chen, Yuan-Tsong .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 7 (04) :317-323

[3]

A marker for Stevens-Johnson syndrome [J].

Chung, WH ;

Hung, SI ;

Hong, HS ;

Hsih, MS ;

Yang, LC ;

Ho, HC ;

Wu, JY ;

Chen, YT .

NATURE, 2004, 428 (6982) :486-486

[4]

Devi K, 2005, Indian J Dermatol Venereol Leprol, V71, P325

[5]

Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: A prospective study in adult and elderly patients with newly diagnosed partial epilepsy [J].

Dogan, Ebru Apaydin ;

Usta, Burcu Ekmekci ;

Bilgen, Rengin ;

Senol, Yesim ;

Aktekin, Berrin .

EPILEPSY & BEHAVIOR, 2008, 13 (01) :156-161

[6]

Frisch P O, 2003, FITZPATRICKS DERMATO, P543

[7]

Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel [J].

Halevy, Sitna ;

Ghislain, Pierre-Dominique ;

Mockenhaupt, Maja ;

Fagot, Jean-Paul E. ;

Bavinck, Jan Nico Bouwes ;

Sidoroff, Alexis ;

Naldi, Luigi ;

Dunant, Ariane ;

Viboud, Cecile ;

Roujeau, Jean-Claude .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2008, 58 (01) :25-32

[8]

Lam Nga-Shuen, 2004, Journal of Microbiology Immunology and Infection, V37, P366

[9]

Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics [J].

Mockenhaupt, M ;

Messenheimer, J ;

Tennis, P ;

Schlingmann, J .

NEUROLOGY, 2005, 64 (07) :1134-1138

[10]

TNFα promoter region gene polymorphisms in carbamazepine-hypersensitive patients [J].

Pirmohamed, M ;

Lin, K ;

Chadwick, D ;

Park, BK .

NEUROLOGY, 2001, 56 (07) :890-896

← 1 2 →