Varicella vaccine for immunocompromised children: Results of collaborative studies in the United States and Canada

被引:66
作者
LaRussa, P
Steinberg, S
Gershon, AA
机构
关键词
D O I
10.1093/infdis/174.Supplement_3.S320
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Varicella vaccine in immunocompromised children was clinically evaluated in 575 US and Canadian children with leukemia in remission by the Varicella Vaccine Collaborative Study, Most children had chemotherapy stopped 1 week before and 1 week after immunization. Steroids were stopped for 3 weeks (1 week before to 2 weeks after vaccination), Varicella vaccine was safe, immunogenic, and effective in leukemic children at risk for serious disease or death from chickenpox. The major side effect was mild rash in 50% similar to 1 month after immunization. About 40% of children who developed rash were treated with acyclovir. Vaccine efficacy was judged by the degree of protection after a household exposure to varicella; of 123 exposed children, 17 (14%) developed a mild form of varicella. The vaccine protected completely against. severe varicella. Leukemic vaccinees were less likely to develop tester than were comparable children with leukemia who had wild type varicella. Thus, varicella vaccine, administered carefully with close follow-up, is extremely beneficial for leukemic children.
引用
收藏
页码:S320 / S323
页数:4
相关论文
共 28 条
[1]  
[Anonymous], HUMAN HERPESVIRUSES
[2]  
ARBETER AM, 1990, PEDIATRICS, V85, P338
[3]   MUCOSAL CELL-MEDIATED-IMMUNITY TO VARICELLA ZOSTER VIRUS - ROLE IN PROTECTION AGAINST DISEASE [J].
BOGGERGOREN, S ;
BERNSTEIN, JM ;
GERSHON, AA ;
OGRA, PL .
JOURNAL OF PEDIATRICS, 1984, 105 (02) :195-199
[4]  
BROYER M, 1985, POSTGRAD MED J, V61, P103
[5]  
BRUNELL PA, 1987, PEDIATRICS, V79, P922
[6]  
FELDMAN S, 1975, PEDIATRICS, V56, P388
[7]  
GERSHON A, 1996, IN PRESS PEDIAT CLIN
[8]  
GERSHON AA, 1986, PEDIATRICS, V78, P757
[9]   PERSISTENCE OF IMMUNITY TO VARICELLA IN CHILDREN WITH LEUKEMIA IMMUNIZED WITH LIVE ATTENUATED VARICELLA VACCINE [J].
GERSHON, AA ;
STEINBERG, SP .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (14) :892-897
[10]   The protective effect of immunologic boosting against zoster: An analysis in leukemic children who were vaccinated against chickenpox [J].
Gershon, AA ;
LaRussa, P ;
Steinberg, S ;
Mervish, N ;
Lo, SH ;
Meier, P .
JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (02) :450-453