α-Synuclein aggregation

被引：8

作者：

Bodles, AM ^{[1
]}

Irvine, GB

机构：

[1] Univ Arkansas Med Sci, Donald W Reynolds Ctr Aging, Little Rock, AR 72205 USA

[2] Queens Univ Belfast, Sch Biol & Biochem, Ctr Med Biol, Peptide & Prot Res Grp, Belfast BT9 7BL, Antrim, North Ireland

来源：

PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 03期

关键词：

alpha-synuclein; NAC; amyloid; aggregation; Parkinson's disease;

D O I：

10.2174/0929866043407084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

alpha-Synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation..

引用

页码：271 / 279

页数：9

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