A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins

被引：90

作者：

Jack, DL ^{[1
]}

Storms, ML ^{[1
]}

Tchieu, JH ^{[1
]}

Paulsen, IT ^{[1
]}

Saier, MH ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

来源：

JOURNAL OF BACTERIOLOGY | 2000年 / 182卷 / 08期

关键词：

D O I：

10.1128/JB.182.8.2311-2313.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.

引用

页码：2311 / 2313

页数：3