Microbial lactate utilization: enzymes, pathogenesis, and regulation

被引：63

作者：

Jiang, Tianyi ^{[1
,2
,3
,4
]}

Gao, Chao ^{[3
]}

Ma, Cuiqing ^{[3
]}

Xu, Ping ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China

[3] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China

[4] Shandong Jianzhu Univ, Sch Municipal & Environm Engn, Jinan 250101, Peoples R China

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 10期

基金：

中国国家自然科学基金;

关键词：

lactate utilization; NAD-independent lactate dehydrogenase; biosensor; biocatalysis; pathogenesis; regulation; CEREVISIAE FLAVOCYTOCHROME B(2); SHEWANELLA-ONEIDENSIS MR-1; BOUND L-LACTATE; CORYNEBACTERIUM-GLUTAMICUM; NEISSERIA-MENINGITIDIS; AEROCOCCUS-VIRIDANS; CRYSTAL-STRUCTURE; BIOTECHNOLOGICAL ROUTES; AMPEROMETRIC BIOSENSOR; STAPHYLOCOCCUS-AUREUS;

D O I：

10.1016/j.tim.2014.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lactate utilization endows microbes with the ability to use lactate as a carbon source. Lactate oxidizing enzymes play key roles in the lactate utilization pathway. Various types of these enzymes have been characterized, but novel ones remain to be identified. Lactate determination techniques and biocatalysts have been developed based on these enzymes. Lactate utilization has also been found to induce pathogenicity of several microbes, and the mechanisms have been investigated. More recently, studies on the structure and organization of operons of lactate utilization have been carried out. This review focuses on the recent progress and future perspectives in understanding microbial lactate utilization.

引用

页码：589 / 599

页数：11

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