Understanding mouse models of disease through metabolomics

被引：59

作者：

Griffin, Julian L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.cbpa.2006.06.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolomics is widely applicable to a number of fields including toxicology, plant metabolism and functional genomics. In the area of functional genomics, a number of studies have demonstrated the potential of this approach, which combines high-throughput metabolite profiling with computer-assisted pattern recognition approaches. In this review, recent applications of metabolomics to understanding mouse models of disease are considered. This includes studies on the impact of mouse strain on disease models, as well as metabolic profiling of cardiovascular, metabolic and neurodegenerative diseases. This versatile tool is set to increase in popularity as functional genomic approaches produce more mouse models for phenotyping.

引用

页码：309 / 315

页数：7

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