Gut Microbiota and Complications of Liver Disease

被引：62

作者：

Acharya, Chathur ^{[1
]}

Bajaj, Jasmohan S. ^{[2
]}

机构：

[1] Virginia Commonwealth Univ, Div Gen Internal Med, 1200 E Broad St, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, McGuire VA Med Ctr, 1201 Broad Rock Blvd, Richmond, VA 23249 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 01期

关键词：

Cirrhosis; Bile acids; Nonalcoholic steatohepatitis; Alcoholic liver disease; Dysbiosis; Microbiome; Firmicutes; Bacteroidetes; INTESTINAL BACTERIAL OVERGROWTH; NECROSIS-FACTOR-ALPHA; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; LEAKY GUT; PARACELLULAR PERMEABILITY; COLONIC INFLAMMATION; ALCOHOLIC CIRRHOSIS; DIABETES-MELLITUS;

D O I：

10.1016/j.gtc.2016.09.013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Chronic liver disease, cirrhosis, and its complications are epidemic worldwide. Most complications are mediated through a dysfunctional gut-liver axis. New techniques have made culture-independent analysis of the gut microbiome widespread. With insight into an unfavorable microbiome (dysbiosis) and how it affects liver disease, investigators have discovered new targets to potentially improve outcomes. Dysbiosis is associated with endotoxemia and propagates liver injury due to nonalcoholic steatohepatitis and alcohol. The composition and functionality of the microbiome changes with the development of cirrhosis, decompensation, and with treatments for these conditions. Gut microbiota can be used to predict clinically relevant outcomes in cirrhosis.

引用

页码：155 / +

页数：17

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