Nosocomial Infection, Length of Stay, and Time-Dependent Bias

被引:73
作者
Beyersmann, Jan [1 ,2 ]
Kneib, Thomas [3 ]
Schumacher, Martin [2 ]
Gastmeier, Petra [4 ]
机构
[1] Univ Freiburg, Freiburg Ctr Data Anal & Modelling, D-79104 Freiburg, Germany
[2] Univ Med Ctr Freiburg, Inst Med Biometry & Med Informat, Munich, Germany
[3] Univ Munich, Dept Stat, Munich, Germany
[4] Charite Univ Med Berlin, Inst Hyg & Environm Med, D-13353 Berlin, Germany
关键词
MULTISTATE MODELS; IMPACT;
D O I
10.1086/596020
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Nosocomial pneumonia and its impact on length of stay are major healthcare concerns. From an epidemiological perspective, nosocomial pneumonia is a time-dependent event. Any statistical analysis that does not explicitly model this time dependency will be biased. The bias is not redeemed by adjusting for baseline information.
引用
收藏
页码:273 / 276
页数:4
相关论文
共 10 条
[1]  
[Anonymous], MODELING SURVIVAL DA
[2]  
[Anonymous], METHODOLOGICALLY FOC
[3]   Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection [J].
Beyersmann, J. ;
Gastmeier, P. ;
Grundmann, H. ;
Baerwolff, S. ;
Geffers, C. ;
Behnke, M. ;
Rueden, H. ;
Schumacher, M. .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2006, 27 (05) :493-499
[4]   The impact of time-dependent bias in proportional hazards modelling [J].
Beyersmann, Jan ;
Wolkewitz, Martin ;
Schumacher, Martin .
STATISTICS IN MEDICINE, 2008, 27 (30) :6439-6454
[5]   An easy mathematical proof showed that time-dependent bias inevitably leads to biased effect estimation [J].
Beyersmann, Jan ;
Gastmeier, Petra ;
Wolkewitz, Martin ;
Schumacher, Martin .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2008, 61 (12) :1216-1221
[6]   Bayesian semiparametric multi-state models [J].
Kneib, Thomas ;
Hennerfeind, Andrea .
STATISTICAL MODELLING, 2008, 8 (02) :169-198
[7]   A simulation-based evaluation of methods to estimate the impact of an adverse event on hospital length of stay [J].
Samore, Matthew H. ;
Shen, Shuying ;
Greene, Tom ;
Stoddard, Greg ;
Sauer, Brian ;
Shinogle, Judith ;
Nebeker, Jonathan ;
Harbarth, Stephan .
MEDICAL CARE, 2007, 45 (10) :S108-S115
[8]   Immortal time bias in pharmacoepidemiology [J].
Suissa, Samy .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 167 (04) :492-499
[9]   Time-dependent bias was common in survival analyses published in leading clinical journals [J].
van Walraven, C ;
Davis, D ;
Forster, AJ ;
Wells, GA .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2004, 57 (07) :672-682
[10]   Risk factors for the development of nosocomial pneumonia and mortality on intensive care units:: application of competing risks models [J].
Wolkewitz, Martin ;
Vonberg, Ralf Peter ;
Grundmann, Hajo ;
Beyersmann, Jan ;
Gastmeier, Petra ;
Barwolff, Sina ;
Geffers, Christine ;
Behnke, Michael ;
Ruden, Henning ;
Schumacher, Martin .
CRITICAL CARE, 2008, 12 (02)