Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors

被引：50

作者：

Andersen, SM

Ekhart, C

Lundt, I

Stütz, AE

机构：

[1] Tech Univ Denmark, Dept Organ Chem, DK-2800 Lyngby, Denmark

[2] Graz Tech Univ, Inst Organ Chem, A-8010 Graz, Austria

来源：

CARBOHYDRATE RESEARCH | 2000年 / 326卷 / 01期

关键词：

trihydroxy azepanes; glycosidase inhibitors; simple carbohydrates;

D O I：

10.1016/S0008-6215(00)00018-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five diastereomeric trideoxy-1,6-iminohexitols were synthesised, and their inhibitory activities were determined against selected glycosidases. For comparison, 1,4,5-trideoxy-l,5-imino-D-lyxo-hexitol, the 4-deoxy derivative of 1-deoxymannojirimicin, was prepared by enzymatic isomerisation of 6-azido-3,6-dideoxy-D-riho-hexose into the corresponding 2-ulose and subsequent hydrogenation accompanied by intramolecular reductive amination. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：22 / 33

页数：12

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