Asymmetric synthesis of aminophosphonic acids and trifluoromethylated derivatives thereof

被引：9

作者：

Yuan, CY ^{[1
]}

Li, SS ^{[1
]}

Xiao, JB ^{[1
]}

Cui, SH ^{[1
]}

Wang, GQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 20032, Peoples R China

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2002年 / 177卷 / 6-7期

关键词：

aminophosphonic acids; asymmetric synthesis; 1,3-PSR; trifluoromethylated derivatives;

D O I：

10.1080/10426500212231

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Various approaches leading to chiral aminophosphonic acids were described. Catalytic asymmetric-induced addition of dialkylphosphite to chiral aldimine gives low ee. value. The diastereoselective alkylation of bicyclic phosphonamide derived from anilinomethylpyrrolidine and followed by subsequent reactions provide much better results. 1,3-Proton Schiff reaction was applied successfully for chiral trifluoromethylated alpha- and/or beta-aminophosphonic acids.

引用

页码：1731 / 1734

页数：4

共 7 条

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[5] 2-W
[6] STUDIES ON ORGANOPHOSPHORUS COMPOUNDS .48. STRUCTURAL EFFECT ON THE INDUCED ASYMMETRIC ADDITION OF DIALKYL PHOSPHITE TO CHIRAL ALDIMINE DERIVATIVES
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