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Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion

被引：24
作者：
Kobayashi, T
Ogawa, S
Yura, T
Yanagi, H
机构：
[1] HSP Res Inst, Shimogyo Ku, Kyoto 6008813, Japan
[2] Kanazawa Univ, Sch Med, Dept Neuroanat, Kanazawa, Ishikawa 9608640, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 267卷 / 03期
关键词：
D O I：
10.1006/bbrc.1999.2052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 150-kDa oxygen-regulated protein (ORP150) is a member of glucose-regulated proteins (GRPs), which are induced by stressful conditions such as oxygen or glucose deprivation. Here we investigated the highly abundant expression of ORP150 in mouse pancreas and its relationship with insulin secretion. Immunohistochemical analysis revealed that ORP150 expression was restricted to islets, especially to beta cells, The beta cell-specific expression was also observed in a mouse insulinoma cell line, MIN6, which secretes insulin in response to increased glucose concentration. Furthermore, ORP150 in islets dramatically diminished by fasting, concomitant with reduction of the serum insulin level. These results strongly suggest the role for ORP150 in insulin secretion, (C) 2000 Academic Press.
引用
收藏
页码：831 / 837
页数：7
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