Apical protein transport

被引：47

作者：

Delacour, D. ^{[1
]}

Jacob, R. ^{[1
]}

机构：

[1] Univ Marburg, Dept Cell Biol & Cell Pathol, D-35033 Marburg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 21期

关键词：

epithelial cells; apical sorting; protein trafficking; cytoskeleton; transport vesicles; membrane fusion;

D O I：

10.1007/s00018-006-6210-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The plasma membrane of epithelial cells and hepatocytes is divided into two separate membrane compartments, the apical and the basolateral domain. This polarity is maintained by intracellular machinery that directs newly synthesized material into the correct target membrane. Apical protein sorting and trafficking require specific signals and different intracellular routes to the cell surface. Some of them depend on the integrity of sphingolipid/cholesterol-enriched membrane microdomains named 'lipid rafts', others use separate transport platforms. Certain characteristics of the heterogeneous population of apical sorting signals are described in this review and cellular factors associated with sorting and transport mechanisms are discussed.

引用

页码：2491 / 2505

页数：15

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