Genetic Architecture of Type 2 Diabetes: Recent Progress and Clinical Implications

被引:54
作者
Grant, Richard W. [1 ,2 ]
Moore, Allan F. [2 ,3 ,4 ,5 ]
Florez, Jose C. [2 ,3 ,4 ,5 ]
机构
[1] Massachusetts Gen Hosp, Dept Med, Div Gen Med, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA
[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Med, Diabet Unit, Ctr Diabet, Boston, MA 02114 USA
[5] Harvard & MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
基金
美国国家卫生研究院;
关键词
GENOME-WIDE ASSOCIATION; CHANNEL SUBUNIT KIR6.2; BODY-MASS INDEX; COMMON VARIANTS; PRO12ALA POLYMORPHISM; INSULIN SENSITIVITY; E23K VARIANT; RISK-FACTORS; FTO GENE; SUSCEPTIBILITY;
D O I
10.2337/dc08-2171
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1107 / 1114
页数:8
相关论文
共 60 条
[1]   The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[2]   Analysis of the relationship between the pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes [J].
Blüher, M ;
Lübben, GR ;
Paschke, R .
DIABETES CARE, 2003, 26 (03) :825-831
[3]   Getting up close and personal with your genome [J].
Bonetta, Laura .
CELL, 2008, 133 (05) :753-756
[4]   Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns [J].
Bonnycastle, Lori L. ;
Willer, Cristen J. ;
Conneely, Karen N. ;
Jackson, Anne U. ;
Burrill, Cecily P. ;
Watanabe, Richard M. ;
Chines, Peter S. ;
Narisu, Narisu ;
Scott, Laura J. ;
Enloe, Sareena T. ;
Swift, Amy J. ;
Duren, William L. ;
Stringham, Heather M. ;
Erdos, Michael R. ;
Riebow, Nancy L. ;
Buchanan, Thomas A. ;
Valle, Timo T. ;
Tuomilehto, Jaakko ;
Bergman, Richard N. ;
Mohlke, Karen L. ;
Boehnke, Michael ;
Collins, Francis S. .
DIABETES, 2006, 55 (09) :2534-2540
[5]   Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas [J].
Bort, R ;
Martinez-Barbera, JP ;
Beddington, RSP ;
Zaret, KS .
DEVELOPMENT, 2004, 131 (04) :797-806
[6]   Personalized medicine in the era of genomics [J].
Burke, Wylie ;
Psaty, Bruce M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (14) :1682-1684
[7]   Health behavior changes after genetic risk assessment for Alzheimer disease: The REVEAL Study [J].
Chao, Serena ;
Roberts, J. Scott ;
Marteau, Theresa M. ;
Silliman, Rebecca ;
Cupples, L. Adrienne ;
Green, Robert C. .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2008, 22 (01) :94-97
[8]   Identification and cloning of a β-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules [J].
Chimienti, F ;
Devergnas, S ;
Favier, A ;
Seve, M .
DIABETES, 2004, 53 (09) :2330-2337
[9]   A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J].
Deeb, SS ;
Fajas, L ;
Nemoto, M ;
Pihlajamäki, J ;
Mykkänen, L ;
Kuusisto, J ;
Laakso, M ;
Fujimoto, W ;
Auwerx, J .
NATURE GENETICS, 1998, 20 (03) :284-287
[10]   Interaction Between Poor Glycemic Control and 9p21 Locus on Risk of Coronary Artery Disease in Type 2 Diabetes [J].
Doria, Alessandro ;
Wojcik, Joanna ;
Xu, Rui ;
Gervino, Ernest V. ;
Hauser, Thomas H. ;
Johnstone, Michael T. ;
Nolan, David ;
Hu, Frank B. ;
Warram, James H. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (20) :2389-2397