Genetic Architecture of Type 2 Diabetes: Recent Progress and Clinical Implications

被引：54

作者：

Grant, Richard W. ^{[1
,2
]}

Moore, Allan F. ^{[2
,3
,4
,5
]}

Florez, Jose C. ^{[2
,3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Div Gen Med, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Med, Diabet Unit, Ctr Diabet, Boston, MA 02114 USA

[5] Harvard & MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA USA

来源：

DIABETES CARE | 2009年 / 32卷 / 06期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; CHANNEL SUBUNIT KIR6.2; BODY-MASS INDEX; COMMON VARIANTS; PRO12ALA POLYMORPHISM; INSULIN SENSITIVITY; E23K VARIANT; RISK-FACTORS; FTO GENE; SUSCEPTIBILITY;

D O I：

10.2337/dc08-2171

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：1107 / 1114

页数：8

共 60 条

[21] Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53) [J].

Gloyn, AL ;

Hashim, Y ;

Ashcroft, SJH ;

Ashfield, R ;

Wiltshire, S ;

Turner, RC .

DIABETIC MEDICINE, 2001, 18 (03) :206-212

[22] Prevalence and treatment of low HDL cholesterol among primary care patients with type 2 diabetes - An unmet challenge for cardiovascular risk reduction [J].

Grant, Richard W. ;

Meigs, James B. .

DIABETES CARE, 2007, 30 (03) :479-484

[23] Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes [J].

Grant, SFA ;

Thorleifsson, G ;

Reynisdottir, I ;

Benediktsson, R ;

Manolescu, A ;

Sainz, J ;

Helgason, A ;

Stefansson, H ;

Emilsson, V ;

Helgadottir, A ;

Styrkarsdottir, U ;

Magnusson, KP ;

Walters, GB ;

Palsdottir, E ;

Jonsdottir, T ;

Gudmundsdottir, T ;

Gylfason, A ;

Saemundsdottir, J ;

Wilensky, RL ;

Reilly, MP ;

Rader, DJ ;

Bagger, Y ;

Christiansen, C ;

Gudnason, V ;

Sigurdsson, G ;

Thorsteinsdottir, U ;

Gulcher, JR ;

Kong, A ;

Stefansson, K .

NATURE GENETICS, 2006, 38 (03) :320-323

[24] Genetic contribution to renal function and electrolyte balance: a twin study [J].

Hunter, DJ ;

de Lange, M ;

Snieder, H ;

MacGregor, AJ ;

Swaminathan, R ;

Thakker, RV ;

Spector, TD .

CLINICAL SCIENCE, 2002, 103 (03) :259-265

[25] Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes [J].

Kang, ES ;

Park, SY ;

Kim, HJ ;

Kim, CS ;

Ahn, CW ;

Cha, BS ;

Lim, SK ;

Nam, CM ;

Lee, HC .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 78 (02) :202-208

[26] TCF7L2 in the Go-DARTS study:: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels [J].

Kimber, C. H. ;

Doney, A. S. F. ;

Pearson, E. R. ;

McCarthy, M. I. ;

Hattersley, A. T. ;

Leese, G. P. ;

Morris, A. D. ;

Palmer, C. N. A. .

DIABETOLOGIA, 2007, 50 (06) :1186-1191

[27] Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin [J].

Knowler, WC ;

Barrett-Connor, E ;

Fowler, SE ;

Hamman, RF ;

Lachin, JM ;

Walker, EA ;

Nathan, DM .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (06) :393-403

[28] Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitus [J].

Langefeld, CD ;

Beck, SR ;

Bowden, DW ;

Rich, SS ;

Wagenknecht, LE ;

Freedman, BI .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2004, 43 (05) :796-800

[29] Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk [J].

Lango, Hana ;

Palmer, Colin N. A. ;

Morris, Andrew D. ;

Zeggini, Eleftheria ;

Hattersley, Andrew T. ;

McCarthy, Mark I. ;

Frayling, Timothy M. ;

Weedon, Michael N. .

DIABETES, 2008, 57 (11) :3129-3135

[30]

Link E, 2008, NEW ENGL J MED, V359, P789, DOI 10.1056/NEJMoa0801936

← 1 2 3 4 5 6 →