Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikis

被引：84

作者：

Janes, SM ^{[1
]}

Watt, FM ^{[1
]}

机构：

[1] CR UK London Res Inst, Keratinocyte Lab, London WC2A 3PX, England

来源：

JOURNAL OF CELL BIOLOGY | 2004年 / 166卷 / 03期

关键词：

keratinocyte; apoptosis; differentiation; Akt; extracellular matrix;

D O I：

10.1083/jcb.200312074

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Stratified squamous epithelia express the alphavbeta5 integrin, but in squamous cell carcinomas (SCCs) there is down-regulation of alphavbeta5 and up-regulation of alphavbeta6. To investigate the significance of this finding, we transduced an alphav-negative human SCC line with retroviral vectors encoding alphav integrins. alphavbeta5-expressing cells underwent suspension-induced apoptosis (anoikis), whereas alpha-negative cells and cells expressing alphavbeta6 did not. Resistance to anoikis correlated with PKB/Akt activation in suspension, but not with changes in PTEN or p110alpha P13 kinase levels.

引用

页码：419 / 431

页数：13

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