Age and sex variation in lipid composition of human fingernail plates

被引：15

作者：

Helmdach, M ^{[1
]}

Thielitz, A ^{[1
]}

Röpke, EM ^{[1
]}

Gollnick, H ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Fac Med, Dept Dermatol & Venerol, D-39120 Magdeburg, Germany

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2000年 / 13卷 / 02期

关键词：

nail lipid biochemistry; nail plates; nail chemistry; aging; sex differences; HPTLC; lipids;

D O I：

10.1159/000029915

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In contrast to epidermal lipid metabolism, the lipid biochemistry of nails has yet been poorly investigated. Our purpose was to define a reference population of healthy individuals as a base for the better understanding of nail diseases and age-induced changes. Therefore, we developed a method of processing and extracting the nail plates enabling us to assess the most relevant epidermal lipid classes by HPTLC, Our study revealed that nail plate lipid composition varies with age and sex: the lipid composition of the fertile years shows distinct profiles compared to that of childhood and old age, suggesting an influence of sex hormones on nail lipogenesis. Our results open the possibility in the future of an easier comparison between healthy and diseased nails and enable us to investigate factors influencing nail lipid composition such as drugs, metabolic diseases, toxic agents, cosmetics and nail therapeutics, Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：111 / 119

页数：9

共 22 条

[1] EPIDERMAL LIPID-METABOLISM IN PSORIASIS AND LICHEN SIMPLEX [J].

COOPER, MF ;

MCGRATH, H ;

SHUSTER, S .

BRITISH JOURNAL OF DERMATOLOGY, 1976, 94 (04) :369-378

[2] AGE-DEPENDENT AND SEX-DEPENDENT CHANGE IN STRATUM-CORNEUM SPHINGOLIPIDS [J].

DENDA, M ;

KOYAMA, J ;

HORI, J ;

HORII, I ;

TAKAHASHI, M ;

HARA, M ;

TAGAMI, H .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1993, 285 (07) :415-417

[3]

Elias Peter M., 1996, Journal of Dermatology (Tokyo), V23, P756

[4]

Fleckman P., 1997, NAILS THERAPY DIAGNO

[5] DECREASED LEVEL OF CERAMIDES IN STRATUM-CORNEUM OF ATOPIC-DERMATITIS - AN ETIOLOGIC FACTOR IN ATOPIC DRY SKIN [J].

IMOKAWA, G ;

ABE, A ;

JIN, K ;

HIGAKI, Y ;

KAWASHIMA, M ;

HIDANO, A .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 96 (04) :523-526

[6]

LAMPE MA, 1983, J LIPID RES, V24, P120

[7] VARIATIONS IN LEVELS OF CHOLESTEROL AND TRIGLYCERIDE IN SKIN SURFACE FAT DURING MENSTRUAL CYCLE [J].

MACDONALD, I ;

CLARKE, G .

BRITISH JOURNAL OF DERMATOLOGY, 1970, 83 (04) :473-+

[8] IDENTIFICATION OF SOME ABNORMAL METABOLITES IN PSORIATIC NAIL USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY [J].

MAEDA, K ;

KAWAGUCHI, S ;

NIWA, T ;

OHKI, T ;

KOBAYASHI, K .

JOURNAL OF CHROMATOGRAPHY, 1980, 221 (02) :199-204

[9] DECREASED STRATUM-CORNEUM CERAMIDES IN ATOPIC INDIVIDUALS - A PATHO-BIOCHEMICAL FACTOR IN XEROSIS [J].

MELNIK, B ;

HOLLMANN, J ;

PLEWIG, G .

BRITISH JOURNAL OF DERMATOLOGY, 1988, 119 (04) :547-549

[10] LIPID-COMPOSITION OF OUTER STRATUM-CORNEUM AND NAILS IN ATOPIC AND CONTROL SUBJECTS [J].

MELNIK, B ;

HOLLMANN, J ;

HOFMANN, U ;

YUH, MS ;

PLEWIG, G .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1990, 282 (08) :549-551

← 1 2 3 →