Synthesis of the tetrasaccharide Glc α (1→3) Man α (1→2) Man α (1→2) Man α (OMe) as inhibitor of calnexin binding to GlcMan9GlcNAc2

被引：8

作者：

Cherif, S ^{[1
]}

Clavel, JM ^{[1
]}

Monneret, C ^{[1
]}

机构：

[1] Inst Curie, CNRS, UMR 176, Sect Rech, F-75248 Paris 05, France

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2002年 / 21卷 / 1-2期

关键词：

D O I：

10.1081/CAR-120003743

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetrasaccharide GlcMan(3) is an inhibitor of GlcMan(9)GlcNAc(2) binding to calnexin, a chaperone protein involved in CFTR-DeltaF 508 retention. A convergent route to its methyl glycoside, the title tetrasaccharide, was developed. The key building block Glc alpha (1-->3) Man 6 was stereoselectively obtained by condensation of a trichloroacetimidate glucosyl donor with an ethyl thiomannopyranoside acceptor. Di-mannose moiety 10 and final compound 12 resulted from thioglycoside activations.

引用

页码：123 / 130

页数：8

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