CEACAM1: contact-dependent control of immunity

被引：418

作者：

Gray-Owen, Scott D. ^{[1
]}

Blumberg, Richard S.

机构：

[1] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Gastroenterol Div, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 06期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

D O I：

10.1038/nri1864

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. Recent studies show that there is an important role for members of the CEACAM family in modulating the immune responses associated with infection, inflammation and cancer. In this Review, we consider the evidence for CEACAM involvement in immunity, with a particular emphasis on CEACAM1, which functions as a regulatory co-receptor for both lymphoid and myeloid cell types.

引用

页码：433 / 446

页数：14

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