Structure of FKBP12.6 in complex with rapamycin

被引：43

作者：

Deivanayagam, CCS ^{[1
]}

Carson, M ^{[1
]}

Thotakura, A ^{[1
]}

Narayana, SVL ^{[1
]}

Chodavarapu, RS ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Sch Optometry, Ctr Macromol Crystallog, Birmingham, AL 35294 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2000年 / 56卷

关键词：

D O I：

10.1107/S0907444999016571

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 Angstrom resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.

引用

页码：266 / 271

页数：6

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