Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses

被引：34

作者：

Berkhoff, E. G. M.

de Wit, E.

Geelhoed-Mieras, M. M.

Boon, A. C. M.

Symons, J.

Fouchier, R. A. M.

Osterhaus, A. D. M. E.

Rimmelzwaan, G. F.

机构：

[1] Erasmus MC, Dept Virol, NL-3000 DR Rotterdam, Netherlands

[2] WHO, Natl Influenza Ctr, Erasmus Med Ctr, NL-3000 DR Rotterdam, Netherlands

来源：

VACCINE | 2006年 / 24卷 / 44-46期

关键词：

cytotoxic T lymphocytes; CTL epitopes; escape; anchor residues; influenza A virus;

D O I：

10.1016/j.vaccine.2006.05.051

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of cytotoxic T lymphocyte (CTL)-inducing vaccines could afford both homo- and heterosubtypic immunity. However, amino acid variation in CTL epitopes associated with escape from CTL-mediated immunity might undermine the use of these vaccines. To assess the impact of amino acid substitutions in highly conserved epitopes on viral fitness and recognition by specific CTL, we performed a mutational analysis of various CTL epitopes. Our findings indicated that fitness costs limited variation in functionally constrained epitopes, especially at anchor residues. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：6594 / 6596

页数：3

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