6-Guanidinopurine nucleosides and their analogues

被引：16

作者：

Cesnek, M ^{[1
]}

Holy, A ^{[1
]}

Masojídková, M ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

TETRAHEDRON | 2002年 / 58卷 / 15期

关键词：

6-guanidinopurines; purine ribonucleosides; purine 2 '-deoxyribonucleosides; acyclic nucleoside phosphonates; acyclic nucleosides; guanidine derivatives;

D O I：

10.1016/S0040-4020(02)00186-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthetic approach to 6-guanidinopurines, their ribonucleosides, 2-deoxyribonucleosides, acyclic nucleoside analogues and acyclic nucleoside phosphonates was developed. The approach consists in the reaction of the 6-chloropurine derivatives with guanidine solution in DMF under DABCO catalysis. This method was used to synthesize 6-guanidinopurine and 2-amino-6-guanidinopurine derivatives. Acyclic nucleosides and acyclic nucleoside phosphonates were also obtained by alkylation of the 6-guanidinopurine bases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2985 / 2996

页数：12

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