The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

被引：475

作者：

Ruggero, D

Montanaro, L

Ma, L

Xu, W

Londei, P

Cardon-Cardo, C

Pandolfi, PP

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Dept Pathol, New York, NY 10021 USA

[3] Univ Bari, Dipartimento Biochim Med & Biol Med, I-70124 Bari, Italy

来源：

NATURE MEDICINE | 2004年 / 10卷 / 05期

关键词：

D O I：

10.1038/nm1042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

引用

页码：484 / 486

页数：3

共 15 条

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